Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxa2  forkhead box A2   (Synonyms: Hnf3b, Hnf-3b, HNF3beta, HNF3-beta, Tcf3b, Tcf-3b)
Results	Reference
1	J:255486 Agbu SO, Liang Y, Liu A, Anderson KV, The small GTPase RSG1 controls a final step in primary cilia initiation. J Cell Biol. 2018 Jan 2;217(1):413-427
1	J:284118 Ahmed M, Marziali LN, Arenas E, Feltri ML, Ffrench-Constant C, Laminin alpha2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development. Development. 2019 Aug 29;146(16):dev172668
1	J:126886 Ahnfelt-Ronne J, Jorgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sorensen J, An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem. 2007 Sep;55(9):925-30
1	J:173604 Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP, Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function. Dev Cell. 2011 Jun 14;20(6):775-87
1	J:121553 Allen BL, Tenzen T, McMahon AP, The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007 May 15;21(10):1244-57
1*	J:98302 Altick AL, Dravis C, Bowdler T, Henkemeyer M, Mastick GS, EphB receptor tyrosine kinases control morphological development of the ventral midbrain. Mech Dev. 2005 Apr;122(4):501-12
1	J:207519 Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R, An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet. 2013 Dec;9(12):e1003973
1*	J:79392 Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL, Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 2002 Oct;129(20):4753-61
1*	J:73074 Bai CB, Joyner AL, Gli1 can rescue the in vivo function of Gli2. Development. 2001 Dec;128(24):5161-72
1	J:222839 Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV, Lineage specificity of primary cilia in the mouse embryo. Nat Cell Biol. 2015 Feb;17(2):113-22
1	J:244630 Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC, Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential. Nat Commun. 2017 Feb 14;8:14428
1	J:301635 Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H, Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic beta-cells. Mol Metab. 2017 Jun;6(6):524-534
1*	J:94057 Besnard V, Wert SE, Hull WM, Whitsett JA, Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns. 2004 Dec;5(2):193-208
1	J:250407 Blanco MJ, Rodriguez-Martin I, Learte AIR, Clemente C, Montalvo MG, Seiki M, Arroyo AG, Sanchez-Camacho C, Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo. PLoS One. 2017;12(9):e0184767
1	J:185651 Bluske KK, Vue TY, Kawakami Y, Taketo MM, Yoshikawa K, Johnson JE, Nakagawa Y, beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development. 2012 Aug;139(15):2692-702
1	J:156272 Bonilla S, Hall AC, Pinto L, Attardo A, Gotz M, Huttner WB, Arenas E, Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors. Glia. 2008 Jun;56(8):809-20
1	J:54240 Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM , Rubenstein JL , Ericson J, Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15;398(6728):622-7
1	J:251822 Cai H, Liu A, Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Dev Biol. 2017 Dec 1;432(1):72-85
1	J:217405 Carcagno AL, Di Bella DJ, Goulding M, Guillemot F, Lanuza GM, Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain. J Neurosci. 2014 Nov 12;34(46):15223-33
1	J:211665 Chaya T, Omori Y, Kuwahara R, Furukawa T, ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J. 2014 Jun 2;33(11):1227-42
1	J:337001 Cheng C, Cong Q, Liu Y, Hu Y, Liang G, Dioneda KMM, Yang Y, Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression. Sci Adv. 2023 Jun 16;9(24):eadf6927
1*	J:178978 Chih B, Liu P, Chinn Y, Chalouni C, Komuves LG, Hass PE, Sandoval W, Peterson AS, A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
1	J:138713 Cho A, Ko HW, Eggenschwiler JT, FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol. 2008 Sep 1;321(1):27-39
1	J:186552 Christopher KJ, Wang B, Kong Y, Weatherbee SD, Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Dev Biol. 2012 Aug 15;368(2):382-92
1	J:291480 Constable S, Long AB, Floyd KA, Schurmans S, Caspary T, The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling. Development. 2020 Feb 3;147(3):dev183301
1	J:143544 Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A, Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev Biol. 2009 Jan 1;325(1):225-37
1	J:166761 Cruz C, Ribes V, Kutejova E, Cayuso J, Lawson V, Norris D, Stevens J, Davey M, Blight K, Bangs F, Mynett A, Hirst E, Chung R, Balaskas N, Brody SL, Marti E, Briscoe J, Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling. Development. 2010 Dec;137(24):4271-82
1	J:167534 Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW, Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech. 2011 Jan;4(1):43-56
1	J:205269 Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW, Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
1	J:65763 Eggenschwiler JT, Anderson KV, Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev Biol. 2000 Nov 15;227(2):648-60
1*	J:104803 Eggenschwiler JT, Bulgakov OV, Qin J, Li T, Anderson KV, Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev Biol. 2006 Feb 1;290(1):1-12
1*	J:70423 Eggenschwiler JT, Espinoza E, Anderson KV, Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 2001 Jul 12;412(6843):194-8
1	J:152551 Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS, The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6
1*	J:35809 Epstein DJ, Marti E, Scott MP, McMahon AP, Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development. 1996 Sep;122(9):2885-94
1	J:124122 Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA, Ang SL, Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007 Aug;134(15):2761-9
1	J:226733 Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E, PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev Cell. 2014 Mar 31;28(6):647-58
1	J:228881 Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hubner W, Brodski C, Tucker KL, Blaess S, Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71
1*	J:262122 Gigante ED, Long AB, Ben-Ami J, Caspary T, Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response. Dev Biol. 2018 May 15;437(2):152-162
1	J:246522 Goetz SC, Bangs F, Barrington CL, Katsanis N, Anderson KV, The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling. PLoS One. 2017;12(3):e0173399
1*	J:217609 Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP, ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014 Oct;141(20):3966-77
1*	J:98371 Gotz K, Briscoe J, Ruther U, Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn. 2005 Jun;233(2):623-30
1	J:83744 Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR, Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003 May 30;113(5):657-70
1	J:143880 Guo C, Qiu HY, Shi M, Huang Y, Johnson RL, Rubinstein M, Chen SD, Ding YQ, Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. J Neurosci. 2008 Dec 24;28(52):14097-106
1	J:186503 Han L, Pan Y, Wang B, Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. J Biol Chem. 2012 Jun 8;287(24):20483-9
1	J:193109 Hayes L, Ralls S, Wang H, Ahn S, Duration of Shh signaling contributes to mDA neuron diversity. Dev Biol. 2013 Feb 1;374(1):115-26
1*	J:174196 Heydeck W, Liu A, PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. Dev Dyn. 2011 Aug;240(8):1938-48
1*	J:154370 Heydeck W, Zeng H, Liu A, Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse. Dev Dyn. 2009 Oct 29;238(12):3035-3042
1	J:199287 Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, McMahon AP, Allen BL, Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013 Aug;140(16):3423-34
1	J:166771 Holz A, Kollmus H, Ryge J, Niederkofler V, Dias J, Ericson J, Stoeckli ET, Kiehn O, Arnold HH, The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development. 2010 Dec;137(24):4249-60
1	J:142506 Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A, C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development. 2008 Dec;135(24):4049-58
1	J:122547 Huang X, Litingtung Y, Chiang C, Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development. 2007 Jun;134(11):2095-105
1	J:76765 Huang Y, Roelink H, McKnight GS, Protein kinase A deficiency causes axially localized neural tube defects in mice. J Biol Chem. 2002 May 31;277(22):19889-96
1	J:100466 Huangfu D, Anderson KV, Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30
1	J:86437 Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV, Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6;426(6962):83-7
1	J:253972 Hwang SH, White KA, Somatilaka BN, Shelton JM, Richardson JA, Mukhopadhyay S, The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner. Development. 2018 Jan 8;145(1):dev154054
1	J:115338 Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y, Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 2006 Nov;133(22):4463-73
1	J:252110 Iulianella A, Sakai D, Kurosaka H, Trainor PA, Ventral neural patterning in the absence of a Shh activity gradient from the floorplate. Dev Dyn. 2018 Jan;247(1):170-184
1*	J:292838 Iulianella A, Stanton-Turcotte D, The Hedgehog receptor Patched1 regulates proliferation, neurogenesis, and axon guidance in the embryonic spinal cord. Mech Dev. 2019 Dec;160:103577
1	J:128441 Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J, Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci. 2007 Nov;10(11):1433-9
1	J:222414 Jarrar W, Vauti F, Arnold HH, Holz A, Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system. Differentiation. 2015 Mar-Apr;89(3-4):70-6
1	J:94269 Jeong J, McMahon AP, Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. 2005 Jan;132(1):143-54
1	J:146200 Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB, Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci. 2009 Feb;12(2):125-31
1	J:266563 Jorgensen MC, de Lichtenberg KH, Collin CA, Klinck R, Ekberg JH, Engelstoft MS, Lickert H, Serup P, Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice. Development. 2018 Sep 3;145(17):dev163568
1	J:184749 Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ, IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport. Dev Cell. 2012 May 15;22(5):940-51
1	J:219821 Kim M, Fontelonga T, Roesener AP, Lee H, Gurung S, Mendonca PR, Mastick GS, Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction. Dev Biol. 2015 Mar 1;399(1):68-79
1	J:130846 Kittappa R, Chang WW, Awatramani RB, McKay RD, The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 2007 Dec;5(12):e325
1*	J:158583 Ko HW, Norman RX, Tran J, Fuller KP, Fukuda M, Eggenschwiler JT, Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell. 2010 Feb 16;18(2):237-47
1	J:221657 Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG, Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26;33(4):373-87
1*	J:311933 Kong JH, Young CB, Pusapati GV, Espinoza FH, Patel CB, Beckert F, Ho S, Patel BB, Gabriel GC, Aravind L, Bazan JF, Gunn TM, Lo CW, Rohatgi R, Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development. 2021 Oct 1;148(19):dev199867
1	J:168620 Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J, A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010 Dec;137(23):4051-60
1	J:169530 Li J, Wang C, Pan Y, Bai Z, Wang B, Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo. Dev Dyn. 2011 Apr;240(4):766-74
1*	J:248981 Li J, Wang C, Wu C, Cao T, Xu G, Meng Q, Wang B, PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant. Dev Biol. 2017 Sep 1;429(1):147-157
1	J:213871 Li X, Liu Z, Qiu M, Yang Z, Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord. Development. 2014 Jul;141(14):2875-84
1	J:151965 Liem KF Jr, He M, Ocbina PJ, Anderson KV, Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13377-82
1	J:180775 Liu J, Heydeck W, Zeng H, Liu A, Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning. Dev Biol. 2012 Feb 15;362(2):141-53
1	J:221426 Liu J, Zeng H, Liu A, The loss of Hh responsiveness by a non-ciliary Gli2 variant. Development. 2015 May 1;142(9):1651-60
1	J:249936 Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Bruchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wuhl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C, Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet. 2017 Jul;49(7):1025-1034
1	J:91298 Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M, PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature. 2004 Jul 1;430(6995):93-8
1	J:219800 Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL, Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
1	J:229947 Luo SX, Huang EJ, Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. Am J Pathol. 2016 Mar;186(3):478-88
1*	J:137199 Lupu F, Alves A, Anderson K, Doye V, Lacy E, Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell. 2008 Jun;14(6):831-42
1	J:228335 Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui CC, Gondo Y, T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455
1	J:221299 Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N, Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance. Development. 2014 Feb;141(3):574-84
1*	J:28010 Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP, Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development. 1995 Aug;121(8):2537-47
1*	J:170258 Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, Ang SL, Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
1	J:211652 Moon H, Song J, Shin JO, Lee H, Kim HK, Eggenschwiller JT, Bok J, Ko HW, Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8541-6
1	J:147574 Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT, Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet. 2009 May 15;18(10):1740-54
1	J:231849 Nouri N, Patel MJ, Joksimovic M, Poulin JF, Anderegg A, Taketo MM, Ma YC, Awatramani R, Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Mol Cell Neurosci. 2015 Sep;68:131-42
1	J:188764 Ocbina PJ, Eggenschwiler JT, Moskowitz I, Anderson KV, Complex interactions between genes controlling trafficking in primary cilia. Nat Genet. 2011 Jun;43(6):547-53
1	J:115577 Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK, Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
1	J:160534 Ono Y, Nakatani T, Minaki Y, Kumai M, The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells. Development. 2010 Jun;137(11):1897-906
1*	J:330741 Orchard P, White JS, Thomas PE, Mychalowych A, Kiseleva A, Hensley J, Allen B, Parker SCJ, Keegan CE, Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice. Hum Mol Genet. 2019 Mar 1;28(5):736-750
1	J:81765 Pabst O, Rummelies J, Winter B, Arnold HH, Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve. Development. 2003 Mar;130(6):1193-202
1	J:121344 Pachikara A, Dolson DK, Martinu L, Riccomagno MM, Jeong Y, Epstein DJ, Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms. Dev Biol. 2007 May 1;305(1):52-62
1*	J:60986 Park HL, Bai C, Platt KA, Matise MP, Beeghly A, Hui CC, Nakashima M, Joyner AL, Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development. 2000 Apr;127(8):1593-605
1	J:215309 Patterson ES, Waller LE, Kroll KL, Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. Dev Biol. 2014 Sep 1;393(1):44-56
1	J:147584 Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN, Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet. 2009 May 15;18(10):1719-39
1	J:80207 Persson M, Stamataki D, te Welscher P, Andersson E, Bose J, Ruther U, Ericson J, Briscoe J, Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 2002 Nov 15;16(22):2865-78
1	J:168317 Qin J, Lin Y, Norman RX, Ko HW, Eggenschwiler JT, Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1456-61
1	J:331697 Ramachandran J, Zhou W, Bardenhagen AE, Nasr T, Yates ER, Zorn AM, Ji H, Vokes SA, Hedgehog regulation of epithelial cell state and morphogenesis in the larynx. Elife. 2022 Nov 18;11
1*	J:103820 Reiter JF, Skarnes WC, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
1*	J:160812 Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J, Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010 Jun 1;24(11):1186-200
1	J:213073 Runck LA, Method A, Bischoff A, Levitt M, Pena A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G, Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93
1	J:257581 Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG, Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS Biol. 2018 Feb;16(2):e2003127
1*	J:267242 Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J, An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014 Nov 5;5:5425
1*	J:273053 Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M, A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015 Oct 13;13(2):326-36
1	J:243907 Snouffer A, Brown D, Lee H, Walsh J, Lupu F, Norman R, Lechtreck K, Ko HW, Eggenschwiler J, Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS Genet. 2017 Aug;13(8):e1006912
1	J:162640 Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y, Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature. 2010 Jul 15;466(7304):378-82
1	J:239367 Stasiulewicz M, Gray SD, Mastromina I, Silva JC, Bjorklund M, Seymour PA, Booth D, Thompson C, Green RJ, Hall EA, Serup P, Dale JK, A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development. 2015 Jul 01;142(13):2291-303
1*	J:216284 Swiderski RE, Nakano Y, Mullins RF, Seo S, Banfi B, A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet. 2014 Oct;10(10):e1004689
1	J:278240 Tahara N, Kawakami H, Chen KQ, Anderson A, Yamashita Peterson M, Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ, Kawakami Y, Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos. Development. 2019 Jul 15;146(14):dev177659
1	J:199133 Tang M, Luo SX, Tang V, Huang EJ, Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev. 2013;8:8
1	J:149534 Tang M, Miyamoto Y, Huang EJ, Multiple roles of {beta}-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development. 2009 Jun;136(12):2027-38
1	J:161771 Tang M, Villaescusa JC, Luo SX, Guitarte C, Lei S, Miyamoto Y, Taketo MM, Arenas E, Huang EJ, Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. J Neurosci. 2010 Jul 7;30(27):9280-91
1	J:108747 Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP, The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006 May;10(5):647-56
1	J:94270 Tian H, Jeong J, Harfe BD, Tabin CJ, McMahon AP, Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development. 2005 Jan;132(1):133-42
1	J:133725 Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR, THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet. 2008 Apr;40(4):403-10
1	J:181006 Tuson M, He M, Anderson KV, Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development. 2011 Nov;138(22):4921-30
1	J:204465 Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S, Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013 Sep;140(18):3731-42
1	J:321159 Walter J, Bolognin S, Poovathingal SK, Magni S, Gerard D, Antony PMA, Nickels SL, Salamanca L, Berger E, Smits LM, Grzyb K, Perfeito R, Hoel F, Qing X, Ohnmacht J, Bertacchi M, Jarazo J, Ignac T, Monzel AS, Gonzalez-Cano L, Kruger R, Sauter T, Studer M, de Almeida LP, Tronstad KJ, Sinkkonen L, Skupin A, Schwamborn JC, The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Rep. 2021 Oct 19;37(3):109864
1	J:284292 Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X, Zheng Y, Sun M, Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 1;9(5):520
1	J:249241 Wang C, Li J, Meng Q, Wang B, Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. Dev Biol. 2017 Oct 1;430(1):156-165
1*	J:260445 Wang C, Li J, Takemaru KI, Jiang X, Xu G, Wang B, Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development. 2018 Mar 15;145(6):dev164236
1	J:175801 Wang H, Lei Q, Oosterveen T, Ericson J, Matise MP, Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS. Development. 2011 Sep;138(17):3711-21
1	J:279272 Wang JJ, Liu HX, Song L, Li HR, Yang YP, Zhang T, Jing Y, Isl-1 positive pharyngeal mesenchyme subpopulation and its role in the separation and remodeling of the aortic sac in embryonic mouse heart. Dev Dyn. 2019 Sep;248(9):771-783
1	J:282458 Wang Y, Zeng H, Liu A, Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia. J Dev Biol. 2019 Feb 19;7(1)
1*	J:154075 Weatherbee SD, Niswander LA, Anderson KV, A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2009 Dec 1;18(23):4565-75
1	J:80206 Wijgerde M, McMahon JA, Rule M, McMahon AP, A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002 Nov 15;16(22):2849-64
1	J:217597 Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV, Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development. 2014 Nov;141(22):4385-94
1	J:242833 Wu C, Li J, Peterson A, Tao K, Wang B, Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Hum Mol Genet. 2017 Jul 01;26(13):2386-2397
1	J:105927 Wu S, Wu Y, Capecchi MR, Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo. Development. 2006 Feb;133(4):581-90
1	J:240543 Xin D, Christopher KJ, Zeng L, Kong Y, Weatherbee SD, IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture. Development. 2017 Apr 15;144(8):1544-1553
1*	J:267206 Xu S, Liu Y, Meng Q, Wang B, Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse. J Cell Sci. 2018 Nov 8;131(21):jcs213710
1	J:192748 Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L, Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012 Oct 1;122(10):3516-28
1	J:335806 Yan L, Yin H, Mi Y, Wu Y, Zheng Y, Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Front Cell Dev Biol. 2023;11:1084245
1	J:298652 Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K, The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. Elife. 2020 Aug 6;9:e57381
1	J:194893 Yu K, McGlynn S, Matise MP, Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
1	J:143585 Yu W, McDonnell K, Taketo MM, Bai CB, Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner. Development. 2008 Nov;135(22):3687-96
1	J:159120 Zeng H, Hoover AN, Liu A, PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Dev Biol. 2010 Mar 15;339(2):418-28